參考文獻 |
1. Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R and et al. Rapidly progressive interstitial renal fibrosis in young women: Association with slimming regimen including chinese herbs. Lancet. 1993; 341(8842): 387-391.
2. De Broe ME. On a nephrotoxic and carcinogenic slimming regimen. American Journal of Kidney Diseases. 1999; 33(6): 1171-1173.
3. Debelle FD, Vanherweghem JL and Nortier JL. Aristolochic acid nephropathy: A worldwide problem. Kidney International. 2008; 74(2): 158-169.
4. Veenstra DL, Best JH, Hornberger J, Sullivan SD and Hricik DE. Incidence and cost of steroid side effects after renal transplantation. Transplant Proc. 1999; 31(1-2): 301-302.
5. Vanhaelen M, Vanhaelen-Fastre R, But P and Vanherweghem JL. Identification of aristolochic acid in chinese herbs. Lancet. 1994; 343(8890): 174.
6. Lai MN, Lai JN, Chen PC, Hsieh SC, Hu FC and Wang JD. Risks of kidney failure associated with consumption of herbal products containing mu tong or fangchi: A population-based case-control study. American Journal of Kidney Diseases. 2010; 55(3): 507-518.
7. Schmeiser HH, Bieler CA, Wiessler M, van Ypersele de Strihou C, Cosyns JP, Schmeiser HH, Bieler CA, Wiessler M, van Ypersele de Strihou C and Cosyns JP. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with chinese herbs nephropathy. Cancer Research. 1996; 56(9): 2025-2028.
8. Cosyns JP. When is "Aristolochic acid nephropathy" More accurate than "Chinese herbs nephropathy"? Kidney International. 2002; 61(3): 1178.
9. Mose JR. The effect of aristolochic acid on the development of methyl-cholanthrene tumours in mice. Osterr Z Onkol. 1975; 2(6): 151-153.
10. Cosyns JP. Aristolochic acid and 'chinese herbs nephropathy': A review of the evidence to date. Drug Safety. 2003; 26(1): 33-48.
11. Nortier JL and Vanherweghem J-L. For patients taking herbal therapy--lessons from aristolochic acid nephropathy. Nephrology Dialysis Transplantation. 2007; 22(6): 1512-1517.
12. Balachandran P, Wei F, Lin RC, Khan IA and Pasco DS. Structure activity relationships of aristolochic acid analogues: Toxicity in cultured renal epithelial cells. Kidney International. 2005; 67(5): 1797-1805.
13. Arlt VM, Stiborova M and Schmeiser HH. Aristolochic acid as a probable human cancer hazard in herbal remedies: A review. Mutagenesis. 2002; 17(4): 265-277.
14. De Broe ME. On a nephrotoxic and carcinogenic slimming regimen.[comment]. American Journal of Kidney Diseases. 1999; 33(6): 1171-1173.
15. Robisch G SO, Göggelmann W. Aristolochic acid is a direct mutagen in salmonella typhimurium. Mutation Research. 1982; 105(4): 201-204.
16. Mengs U. On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid. Archives of Toxicology. 1983; 52(3): 209-220.
17. Schmeiser HH PB, Wiessler M. Mutagenicity of the two main components of commercially available carcinogenic aristolochic acid in salmonella typhimurium. Cancer Lett. 1984; 23(1): 98-101.
18. FDA. Aristolochic acid: Letter to industry - fda concerned about botanical products, including dietary supplements, containing aristolochic acid. http://www.fda.gov/Food/DietarySupplements/Alerts/ucm095290.htm, 2000.
19. WHO. Pharmaceuticals: Restrictions in use and availability. http://whqlibdoc.who.int/hq/2003/EDM_QSM_2003.5.pdf, 2003.
20. 行政院衛生署中醫藥委員會. 含馬兜鈴酸中(藥)劑處理專區. http://www.ccmp.gov.tw/public/public.asp?selno=561&relno=561&level=C,
21. Stiborova M, Frei E, Arlt VM and Schmeiser HH. The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: Urgent questions and difficult answers. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009; 153(1): 5-11.
22. Stiborova M, Frei E and Schmeiser HH. Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid. Kidney International. 2008; 73(11): 1209-1211.
23. Krumbiegel G, Hallensleben J, Mennicke WH, Rittmann N and Roth HJ. Studies on the metabolism of aristolochic acids i and ii. Xenobiotica. 1987; 17(8): 981-991.
24. Chen W, Chen Y and Li A. [the clinical and pathological manifestations of aristolochic acid nephropathy--the report of 58 cases]. Zhonghua Yi Xue Za Zhi. 2001; 81(18): 1101-1105.
25. van Ypersele de Strihou C and Vanherweghem JL. The tragic paradigm of chinese herbs nephropathy. Nephrology Dialysis Transplantation. 1995; 10(2): 157-160.
26. Reginster F, Jadoul M, van Ypersele de Strihou C, Reginster F, Jadoul M and van Ypersele de Strihou C. Chinese herbs nephropathy presentation, natural history and fate after transplantation. Nephrology Dialysis Transplantation. 1997; 12(1): 81-86.
27. Kabanda A, Jadoul M, Lauwerys R, Bernard A and van Ypersele de Strihou C. Low molecular weight proteinuria in chinese herbs nephropathy. Kidney International. 1995; 48(5): 1571-1576.
28. Depierreux M, Van Damme B, Vanden Houte K and Vanherweghem JL. Pathologic aspects of a newly described nephropathy related to the prolonged use of chinese herbs. American Journal of Kidney Diseases. 1994; 24(2): 172-180.
29. Van Ypersele De Strihou C and Jadoul M. Progression rate of chinese herb nephropathy: Impact of aristolochia fangchi ingested dose.[comment]. Nephrology Dialysis Transplantation. 2002; 17(10): 1852; author reply 1852.
30. Chen SM, Fan MY, Tseng CC, Ho Y and Hsu KY. Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits. Toxicon. 2007; 50(2): 180-188.
31. De Broe ME and Elseviers MM. Analgesic nephropathy. The New England Journal of Medicine. 1998; 338(7): 446-452.
32. Hrabar A, Ceovic S, Aleraj B, Cvoriscec D and Hall PW, 3rd. Relationship of anemia to balkan endemic nephropathy. Kidney International. Supplement. 1991; 34: S44-45.
33. Raicevic S, Trnacevic S, Hranisavljevic J and Vucelic D. Renal function, protein excretion, and pathology of balkan endemic nephropathy. Ii. Protein excretion. Kidney International. Supplement. 1991; 34: S52-56.
34. Stefanović V. Analgesic nephropathy, balkan endemic nephropathy and chinese herbs nephropathy: Separate tubulointerstitial kidney diseases associated with urothelial malignancy. Facta Universitatis Series: Medicine and Biology. 2002; 9(1): 1-6.
35. Cosyns JP, Dehoux JP, Guiot Y, Goebbels RM, Robert A, Bernard AM and van Ypersele de Strihou C. Chronic aristolochic acid toxicity in rabbits: A model of chinese herbs nephropathy?[see comment]. Kidney International. 2001; 59(6): 2164-2173.
36. Li Y, Liu Z, Guo X, Shu J, Chen Z, Li L, Li Y, Liu Z, Guo X, Shu J, Chen Z and Li L. Aristolochic acid i-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro. Archives of Toxicology. 2006; 80(8): 524-532.
37. Lebeau C, Debelle FD, Arlt VM, Pozdzik A, De Prez EG, Phillips DH, Deschodt-Lanckman MM, Vanherweghem JL, Nortier JL, Lebeau C, Debelle FD, Arlt VM, Pozdzik A, De Prez EG, Phillips DH, Deschodt-Lanckman MM, Vanherweghem J-L and Nortier JL. Early proximal tubule injury in experimental aristolochic acid nephropathy: Functional and histological studies. Nephrology Dialysis Transplantation. 2005; 20(11): 2321-2332.
38. Bakhiya N, Arlt VM, Bahn A, Burckhardt G, Phillips DH and Glatt H. Molecular evidence for an involvement of organic anion transporters (oats) in aristolochic acid nephropathy. Toxicology. 2009; 264(1-2): 74-79.
39. Vanherweghem JL, Abramowicz D, Tielemans C, Depierreux M, Vanherweghem JL, Abramowicz D, Tielemans C and Depierreux M. Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: A pilot study in chinese herbs nephropathy. American Journal of Kidney Diseases. 1996; 27(2): 209-215.
40. Pozdzik AA, Salmon IJ, Husson CP, Decaestecker C, Rogier E, Bourgeade MF, Deschodt-Lanckman MM, Vanherweghem JL and Nortier JL. Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy. Nephrology, Dialysis, Transplantation. 2008; 23(8): 2480-2491.
41. Li. J, Zhang. Z, Wang. D, Wang. Y, Li. Y and Wu. G. Tgf-beta 1/smads signaling stimulates renal interstitial fibrosis in experimental aan. Journal of Receptors and Signal Transduction. 2009; 29(5): 280-285.
42. Zhou. L, Fu. P, Huang. XR, Liu. F, Chung. AC, Lai. KN and Lan. HY. Mechanism of chronic aristolochic acid nephropathy: Role of smad3. American Journal of Physiology-Renal Physiology. 2010; 298(4): F1006-1017.
43. Cosyns JP, Jadoul M, Squifflet JP, De Plaen JF, Ferluga D and van Ypersele de Strihou C. Chinese herbs nephropathy: A clue to balkan endemic nephropathy? Kidney International. 1994; 45(6): 1680-1688.
44. Wen YJ, Qu L and Li XM. Ischemic injury underlies the pathogenesis of aristolochic acid-induced acute kidney injury. Translational Research. 2008; 152(1): 38-46.
45. Yang L, Li X and Wang H. Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis. Nephrology Dialysis Transplantation. 2007; 22(2): 445-456.
46. Hsin YH, Cheng CH, Tzen JT, Wu MJ, Shu KH and Chen HC. Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells. Apoptosis. 2006; 11(12): 2167-2177.
47. Debelle FD, Nortier JL, Husson CP, De Prez EG, Vienne AR, Rombaut K, Salmon IJ, Deschodt-Lanckman MM and Vanherweghem JL. The renin-angiotensin system blockade does not prevent renal interstitial fibrosis induced by aristolochic acids. Kidney International. 2004; 66(5): 1815-1825.
48. Zhu S, Liu J, Chen L, Li Y, Yao J, Jin C, Wang Z, Wang L, Wu P, Luo Q, Zhou J, Zhu S, Liu J, Chen L, Li Y, Yao J, Jin C, Wang Z, Wang L, Wu P, Luo Q and Zhou J. Chemopreventive effect of five drugs on renal interstitial fibrosis induced by an aristolochic acid-containing chinese herb in rats. American Journal of Nephrology. 2005; 25(1): 23-29.
49. Zhang C, Chen YP, Dong HR and Qiu CB. [the therapeutic effects of bosentan and valsartan on renal interstitial fibrosis of chronic aristolochic acid nephropathy]. Zhonghua Yi Xue Za Zhi. 2005; 85(37): 2601-2606.
50. Wang HL, Zhang JY and Huang J. [effects of glycyrrihizic acid and prednisone on pathological and ultrastructural changes of kidney in rats with chronic aristolochic acid nephropathy]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007; 27(1): 45-49.
51. Wang HT, Wang YM, Liang YP, Liu YJ and Peng W. [wenyang huoxue recipe up-regulates the expression of angiopoietin-1 mrna in rats with chronic aristolochic acid nephropathy]. Zhong Xi Yi Jie He Xue Bao. 2008; 6(5): 508-511.
52. Jackson L, Kofman S, Weiss A and Brodovsky H. Aristolochic acid (nsc-50413): Phase i clinical study. Cancer Chemotherapy Reports. Part 1. 1964; 42: 35-37.
53. Mengs U. Acute toxicity of aristolochic acid in rodents. Archives of Toxicology. 1987; 59(5): 328-331.
54. Mengs U and Stotzem CD. Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. Archives of Toxicology. 1993; 67(5): 307-311.
55. Sato N, Takahashi D, Chen SM, Tsuchiya R, Mukoyama T, Yamagata S, Ogawa M, Yoshida M, Kondo S, Satoh N and Ueda S. Acute nephrotoxicity of aristolochic acids in mice. Journal of Pharmacy and Pharmacology. 2004; 56(2): 221-229.
56. Nouwen EF ZM, Savin M. Induction of apoptosis in the rat kidney by aristolochic acid i. ASN Annual Meeting. 1995; 1002.
57. Cosyns JP, Dehoux JP, Guiot Y, Goebbels RM, Robert A, Bernard AM and van Ypersele de Strihou C. Chronic aristolochic acid toxicity in rabbits: A model of chinese herbs nephropathy? Kidney International. 2001; 59(6): 2164-2173.
58. Zheng F, Zhang X and Huang Q. [establishment of model of aristolochic acid-induced chronic renal interstitial fibrosis in rats]. Chung-Hua i Hsueh Tsa Chih [Chinese Medical Journal]. 2001; 81(18): 1095-1100.
59. Debelle FD, Nortier JL, De Prez EG, Garbar CH, Vienne AR, Salmon IJ, Deschodt-Lanckman MM and Vanherweghem J-L. Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. Journal of the American Society of Nephrology. 2002; 13(2): 431-436.
60. Liu Y. Renal fibrosis: New insights into the pathogenesis and therapeutics. Kidney International. 2006; 69(2): 213-217.
61. El Nahas AM, Muchaneta-Kubara EC, Essawy M and Soylemezoglu O. Renal fibrosis: Insights into pathogenesis and treatment. International Journal of Biochemistry and Cell Biology. 1997; 29(1): 55-62.
62. Efstratiadis G, Divani M, Katsioulis E and Vergoulas G. Renal fibrosis. Hippokratia. 2009; 13(4): 224-229.
63. Eddy AA and Eddy AA. Molecular basis of renal fibrosis. Pediatric Nephrology. 2000; 15(3-4): 290-301.
64. Becker GJ and Hewitson TD. The role of tubulointerstitial injury in chronic renal failure. Current Opinion in Nephrology and Hypertension. 2000; 9(2): 133-138.
65. Eddy AA. Molecular insights into renal interstitial fibrosis. Journal of the American Society of Nephrology. 1996; 7(12): 2495-2508.
66. Liu Y and Liu Y. Renal fibrosis: New insights into the pathogenesis and therapeutics. Kidney International. 2006; 69(2): 213-217.
67. Branton MH and Kopp JB. Tgf-beta and fibrosis. Microbes and Infection. 1999; 1(15): 1349-1365.
68. Garcia-Sanchez O, Lopez-Hernandez FJ and Lopez-Novoa JM. An integrative view on the role of tgf-beta in the progressive tubular deletion associated with chronic kidney disease. Kidney International. 2010; [Epub ahead of print].
69. Denicourt C and Dowdy SF. Another twist in the transforming growth factor β-induced cell-cycle arrest chronicle. Proceedings of the National Academy of Sciences. 2003; 100(26): 15290-15291.
70. Blobe GC, Schiemann WP and Lodish HF. Role of transforming growth factor beta in human disease. The New England Journal of Medicine. 2000; 342(18): 1350-1358.
71. Border WA and Noble NA. Tgf-beta in kidney fibrosis: A target for gene therapy. Kidney International. 1997; 51(5): 1388-1396.
72. Becker GJ and Hewitson TD. The interstitium in renal disease. Journal of Internal Medicine. 1997; 242(2): 93-97.
73. Liu Y and Liu Y. Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms of action. American Journal of Physiology - Renal Physiology. 2004; 287(1): F7-16.
74. Liu Y, Yang J, Liu Y and Yang J. Hepatocyte growth factor: New arsenal in the fights against renal fibrosis?[comment]. Kidney International. 2006; 70(2): 238-240.
75. Liu Y and Liu Y. Hepatocyte growth factor and the kidney. Current Opinion in Nephrology and Hypertension. 2002; 11(1): 23-30.
76. Matsumoto K, Nakamura T, Matsumoto K and Nakamura T. Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases. Kidney International. 2001; 59(6): 2023-2038.
77. Wang SN, Lapage J and Hirschberg R. Glomerular ultrafiltration and apical tubular action of igf-i, tgf-beta, and hgf in nephrotic syndrome. Kidney International. 1999; 56(4): 1247-1251.
78. Matsumoto K, Nakamura T, Matsumoto K and Nakamura T. Emerging multipotent aspects of hepatocyte growth factor. Journal of Biochemistry. 1996; 119(4): 591-600.
79. Haas CS, Gleason B, Lin S, Tramonti G and Kanwar YS. Matrix metalloproteinases in renal development. Connective Tissue Research. 2004; 45(2): 73-85.
80. Parks WC, Wilson CL and Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nature Reviews Immunology. 2004; 4(8): 617-629.
81. Ronco P and Chatziantoniou C. Matrix metalloproteinases and matrix receptors in progression and reversal of kidney disease: Therapeutic perspectives. Kidney International. 2008; 74(7): 873-878.
82. Lelongt B, Legallicier B, Piedagnel R and Ronco P. Do matrix metalloproteinases mmp-2 and mmp-9 (gelatinases) play a role in renal development, physiology and glomerular diseases? Current Opinion in Nephrology and Hypertension. 2001; 10: 7-12.
83. 賴榮祥, "原色生藥學 ", 創譯出版社, 2000, pp. 44-50.
84. Ma XQ, Shi Q, Duan JA, Dong TT and Tsim KW. Chemical analysis of radix astragali (huangqi) in china: A comparison with its adulterants and seasonal variations. Journal of Agricultural and Food Chemistry. 2002; 50(17): 4861-4866.
85. Huang X, Liu Y, Song F, Liu Z and Liu S. Studies on principal components and antioxidant activity of different radix astragali samples using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. Talanta. 2009; 78(3): 1090-1101.
86. Tanaka K, Tamura T, Fukuda S, Batkhuu J, Sanchir C and Komatsu K. Quality evaluation of astragali radix using a multivariate statistical approach. Phytochemistry. 2008; 69: 2081-2087.
87. Xia GP, Liu P and Han YM. [determination of the total content of astragaloside iv in radix astragali]. Zhong Yao Cai. 2008; 31(3): 385-387.
88. Dou L, Feng L and Xu X. Effects of astragalus membranaceus on urinary endothelin in patients with incipient diabetic nephropathy. Chinese Journal of Integrative Medicine. 2000; 6(4): 263-265.
89. Zhang J, Xie X, Li C and Fu P. Systematic review of the renal protective effect of astragalus membranaceus (root) on diabetic nephropathy in animal models. Journal of Ethnopharmacology. 2009; 126(2): 189-196.
90. Zuo C, Xie XS, Qiu HY, Deng Y, Zhu D and Fan JM. Astragalus mongholicus ameliorates renal fibrosis by modulating hgf and tgf-beta in rats with unilateral ureteral obstruction. Journal of Zhejiang University-SCIENCE B. 2009; 10(5): 380-390.
91. Sheng BW, Chen XF, Zhao J, He DL and Nan XY. Astragalus membranaceus reduces free radical-mediated injury to renal tubules in rabbits receiving high-energy shock waves. Chinese Medical Journal (English). 2005; 118(1): 43-49.
92. Wojcikowski K, Wohlmuth H, Johnson DW and Gobe G. Effect of astragalus membranaceus and angelica sinensis combined with enalapril in rats with obstructive uropathy. Phytotherapy Research. 2009.
93. Meng L, Qu L, Tang J, Cai SQ, Wang H and Li X. A combination of chinese herbs, astragalus membranaceus var. Mongholicus and angelica sinensis, enhanced nitric oxide production in obstructed rat kidney. Vascular Pharmacology. 2007; 47(2-3): 174-183.
94. Wang H, Li J, Yu L, Zhao Y and Ding W. Antifibrotic effect of the chinese herbs, astragalus mongholicus and angelica sinensis, in a rat model of chronic puromycin aminonucleoside nephrosis. Life Sciences. 2004; 74(13): 1645-1658.
95. Jing L and Gao ZY. [retrospective analysis on chinese medicinal treatment on 302 chronic heart failure patients of coronary heart disease and diabetes]. Zhongguo Zhong Yao Za Zhi. 2008; 33(19): 2253-2256.
96. Zhang JG, Yang N and He H. [effect of astraglus injection on serum apoptosis relevant factors in patients with chronic heart failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005; 25(5): 400-403.
97. 吳發寶 and 陳希元. 黃芪藥理作用研究綜述. 中藥材. 2004; 27(2): 232-234.
98. 高木敬次郎, 木村正康 and 林大楨編譯, 漢方藥理學, 文光圖書有限公司, 2007.
99. Yao LM, Liu TW and Wu WF. [effects of astragalus injection in reversing left ventricular hypertrophy induced by renal hypertension in rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009; 29(10): 918-921.
100. Liu ZQ, Li QZ and Qin GJ. [effect of astragalus injection on platelet function and plasma endothelin in patients with early stage diabetic nephropathy]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001; 21(4): 274-276.
101. Hei ZQ, Huang HQ, Zhang JJ, Chen BX and Li XY. Protective effect of astragalus membranaceus on intestinal mucosa reperfusion injury after hemorrhagic shock in rats. World Journal of Gastroenterology. 2005; 11(32): 4986-4991.
102. Zhang BQ, Hu SJ, Qiu LH, Zhu JH, Xie XJ, Sun J, Zhu ZH, Xia Q and Bian K. Effects of astragalus membranaceus and its main components on the acute phase endothelial dysfunction induced by homocysteine. Vascular Pharmacology. 2007; 46(4): 278-285.
103. Yu SY, Ouyang HT, Yang JY, Huang XL, Yang T, Duan JP, Cheng JP, Chen YX, Yang YJ and Qiong P. Subchronic toxicity studies of radix astragali extract in rats and dogs. Journal of Ethnopharmacology. 2007; 110(2): 352-355.
104. Matkovic Z, Zivkovic V, Korica M, Plavec D, Pecanic S and Tudoric N. Efficacy and safety of astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytotherapy Research. 2010; 24(2): 175-181.
105. Lee SJ, Oh SG, Seo SW, Ahn HJ, Geum D, Cho JJ and Park CS. Oral administration of astragalus membranaceus inhibits the development of dnfb-induced dermatitis in nc/nga mice. Biological and Pharmaceutical Bulletin. 2007; 30(8): 1468-1471.
106. Mao X, Piao X, Lai C, Li D, Xing J and BL. S. Effects of beta-glucan obtained from the chinese herb astragalus membranaceus and lipopolysaccharide challenge on performance, immunological, adrenal, and somatotropic responses of weanling pigs. Journal of Animal Science. 2005; 83(12): 2775-2782.
107. Wu P, Dugoua JJ, Eyawo O and Mills EJ. Traditional chinese medicines in the treatment of hepatocellular cancers: A systematic review and meta-analysis. Journal of Experimental and Clinical Cancer Research. 2009; 28: 112.
108. Cui R, He J, Wang B, Zhang F, Chen G, Yin S and Shen H. Suppressive effect of astragalus membranaceus bunge on chemical hepatocarcinogenesis in rats. Cancer Chemotherapy and Pharmacology. 2003; 51(1): 75-80.
109. Zhu XL and Zhu BD. Mechanisms by which astragalus membranaceus injection regulates hematopoiesis in myelosuppressed mice. Phytotherapy Research. 2007; 21(7): 663-667.
110. Chang MS, Kim do R, Ko EB, Choi BJ, Park SY, Kang SA and Park SK. Treatment with astragali radix and angelicae radix enhances erythropoietin gene expression in the cyclophosphamide-induced anemic rat. Journal of Medicinal Food. 2009; 12(3): 637-642.
111. Lee JJ. A phase ii study of an herbal decoction that includes astragali radix for cancer-associated anorexia in patients with advanced cancer. Integrative Cancer Therapies. 2010; 9(1): 24-31.
112. Tang LL, Sheng JF, Xu CH and Liu KZ. Clinical and experimental effectiveness of astragali compound in the treatment of chronic viral hepatitis b. Journal of International Medical Research. 2009; 37(3): 662-667.
113. Sun WY, Wei W, Gui SY, Wu L and Wang H. Protective effect of extract from paeonia lactiflora and astragalus membranaceus against liver injury induced by bacillus calmette-guerin and lipopolysaccharide in mice. Basic & Clinical Pharmacology & Toxicology. 2008; 103(2): 143-149.
114. Haines CJ, Lam PM, Chung TK, Cheng KF and Leung PC. A randomized, double-blind, placebo-controlled study of the effect of a chinese herbal medicine preparation (dang gui buxue tang) on menopausal symptoms in hong kong chinese women. Climacteric. 2008; 11(3): 244-251.
115. Tohda C, Tamura T, Matsuyama S and Komatsu K. Promotion of axonal maturation and prevention of memory loss in mice by extracts of astragalus mongholicus. British Journal of Pharmacology. 2006; 149(5): 532-541.
116. Qi L-W, Yu Q-T, Yi L, Ren M-T, Wen X-D, Wang Y-X and Li P. Simultaneous determination of 15 marker constituents in various radix astragali preparations by solid-phase extraction and high-performance liquid chromatography. Journal of Separation Science. 2008; 31: 97-106.
117. Lv L, Wu SY, Wang GF, Zhang JJ, Pang JX, Liu ZQ, Xu W, Wu SG and Rao JJ. Effect of astragaloside iv on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Phytotherapy Research. 2010; 24(2): 219-224.
118. Yin X, Zhang Y, Wu H, Zhu X, Zheng X, Jiang S, Zhuo H, Shen J, Li L and Qiu J. Protective effects of astragalus saponin i on early stage of diabetic nephropathy in rats. Journal of Pharmacological Sciences. 2004; 95(2): 256-266.
119. Yuan W, Zhang Y, Ge Y, Yan M, Kuang R and Zheng X. Astragaloside iv inhibits proliferation and promotes apoptosis in rat vascular smooth muscle cells under high glucose concentration in vitro. Planta Medica. 2008; 74(10): 1259-1264.
120. Yu J, Zhang Y, Sun S, Shen J, Qiu J, Yin X, Yin H and Jiang S. Inhibitory effects of astragaloside iv on diabetic peripheral neuropathy in rats. Canadian Journal of Physiology and Pharmacology. 2006; 84(6): 579-587.
121. Zhang ZC, Li SJ, Yang YZ, Chen RZ, Ge JB and Chen HZ. Effect of astragaloside on cardiomyocyte apoptosis in murine coxsackievirus b3 myocarditis. Journal of Asian Natural Products Research. 2007; 9(2): 145-151.
122. Meng D, Chen XJ, Bian YY, Li P, Yang D and Zhang JN. Effect of astragalosides on intracellular calcium overload in cultured cardiac myocytes of neonatal rats. American Journal of Chinese Medicine. 2005; 33(1): 11-20.
123. Xu XL, Ji H, Gu SY, Shao Q, Huang QJ and Cheng YP. Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside iv in myocardial injury in vivo. European Journal of Pharmacology. 2007; 568(1-3): 203-212.
124. Chen XJ, Meng D, Feng L, Bian YY, Li P, Yang D, Cao KJ and Zhang JN. Protective effect of astragalosides on myocardial injury by isoproterenol in sd rats. American Journal of Chinese Medicine. 2006; 34(6): 1015-1025.
125. Shi H, Ma C, Liu Y, Zhou J, Hu Z and Wu D. [inhibitory effect on activated renin-angiotensin system by astragaloside iv in rats with pressure-overload induced cardiac hypertrophy]. Zhongguo Zhong Yao Za Zhi. 2009; 34(24): 3242-3246.
126. Wang D-Q, Shen W-M and Tian Y-P. The effects of the three components isolated from astragalus mongholicus bunge on scavenging free redical. Chinese Pharmacological Bulletin. 1994; 10(2): 129-132.
127. Yin X, Zhang Y, Yu J, Zhang P, Shen J, Qiu J, Wu H and Zhu X. The antioxidative effects of astragalus saponin i protect against development of early diabetic nephropathy. Journal of Pharmacological Sciences. 2006; 101(2): 166-173.
128. Chan WS, Durairajan SS, Lu JH, Wang Y, Xie LX, Kum WF, Koo I, Yung KK and Li M. Neuroprotective effects of astragaloside iv in 6-hydroxydopamine-treated primary nigral cell culture. Neurochemistry International. 2009; 55(6): 414-422.
129. Luo Y, Qin Z, Hong Z, Zhang X, Ding D, Fu JH, Zhang WD and Chen J. Astragaloside iv protects against ischemic brain injury in a murine model of transient focal ischemia. Neuroscience Letters. 2004; 363(3): 218-223.
130. Lei H, Wang B, Li WP, Yang Y, Zhou AW and Chen MZ. Anti-aging effect of astragalosides and its mechanism of action. Acta Pharmacologica Sinica. 2003; 24(3): 230-234.
131. Wang YP, Li XY, Song CQ and Hu ZB. Effect of astragaloside iv on t, b lymphocyte proliferation and peritoneal macrophage function in mice. Acta Pharmacologica Sinica. 2002; 23(3): 263-266.
132. Du Q, Chen Z, Zhou LF, Zhang Q, Huang M and Yin KS. Inhibitory effects of astragaloside iv on ovalbumin-induced chronic experimental asthma. Canadian Journal of Physiology and Pharmacology. 2008; 86(7): 449-457.
133. Gui SY, Wei W, Wang H, Wu L, Sun WY, Chen WB and Wu CY. Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats. Journal of Ethnopharmacology. 2006; 103(2): 154-159.
134. Shao BM, Xu W, Dai H, Tu P, Li Z and Gao XM. A study on the immune receptors for polysaccharides from the roots of astragalus membranaceus, a chinese medicinal herb. Biochemical and Biophysical Research Communications. 2004; 320(4): 1103-1111.
135. Lee KY and Jeon YJ. Macrophage activation by polysaccharide isolated from astragalus membranaceus. International Immunopharmacology. 2005; 5(7-8): 1225-1233.
136. Xu HD, You CG, Zhang RL, Gao P and Wang ZR. Effects of astragalus polysaccharides and astragalosides on the phagocytosis of mycobacterium tuberculosis by macrophages. Journal of International Medical Research. 2007; 35(1): 84-90.
137. Yuan Y, Sun M and Li KS. Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of tnf-alpha and interleukin-8. World Journal of Gastroenterology. 2009; 15(29): 3676-3680.
138. Li SP, Zhao XJ and Wang JY. Synergy of astragalus polysaccharides and probiotics (lactobacillus and bacillus cereus) on immunity and intestinal microbiota in chicks. Poultry Science. 2009; 88(3): 519-525.
139. Xue J, Xu Y, Zhang Z, Shen G and Zeng G. The effect of astragapolysaccharide on the lymphocyte proliferation and airway inflammation in sensitized mice. Journal of Tongji Medical University. 1999; 19(1): 20-22, 30.
140. Li RJ, Qiu SD, Chen HX, Tian H and Wang HX. The immunotherapeutic effects of astragalus polysaccharide in type 1 diabetic mice. Biological and Pharmaceutical Bulletin. 2007; 30(3): 470-476.
141. Zhang YW, Wu CY and Cheng JT. Merit of astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mrna expressions of nf-kappab and ikappab in renal cortex of streptozotoxin-induced diabetic rats. Journal of Ethnopharmacology. 2007; 114(3): 387-392.
142. Li S, Zhang Y and Zhao J. Preparation and suppressive effect of astragalus polysaccharide in glomerulonephritis rats. International Immunopharmacology. 2007; 7(1): 23-28.
143. Chen W, Li YM and Yu MH. Effects of astragalus polysaccharides on chymase, angiotensin-converting enzyme and angiotensin ii in diabetic cardiomyopathy in hamsters. Journal of International Medical Research. 2007; 35(6): 873-877.
144. Wang YF, Yang XF, Cheng B, Mei CL, Li QX, Xiao H, Zeng QT, Liao YH and Liu K. Protective effect of astragalus polysaccharides on atp binding cassette transporter a1 in thp-1 derived foam cells exposed to tumor necrosis factor-alpha. Phytotherapy Research. 2010; 24(3): 393-398.
145. Qi LW, Yu QT, Li P, Li SL, Wang YX, Sheng LH and Yi L. Quality evaluation of radix astragali through a simultaneous determination of six major active isoflavonoids and four main saponins by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. Journal of Chromatography A. 2006; 1134(1-2): 162-169.
146. Kuo YH, Tsai WJ, Loke SH, Wu TS and Chiou WF. Astragalus membranaceus flavonoids (amf) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming. Journal of Ethnopharmacology. 2009; 122(1): 28-34.
147. Zhu H, Zhang Y, Ye G, Li Z, Zhou P and Huang C. In vivo and in vitro antiviral activities of calycosin-7-o-beta-d-glucopyranoside against coxsackie virus b3. Biological and Pharmaceutical Bulletin. 2009; 32(1): 68-73.
148. Wu XL, Wang YY, Cheng J and Zhao YY. Calcium channel blocking activity of calycosin, a major active component of astragali radix, on rat aorta. Acta Pharmacologica Sinica. 2006; 27(8): 1007-1012.
149. Ma W, Nomura M, Takahashi-Nishioka T and Kobayashi S. Combined effects of fangchinoline from stephania tetrandra radix and formononetin and calycosin from astragalus membranaceus radix on hyperglycemia and hypoinsulinemia in streptozotocin-diabetic mice. Biological and Pharmaceutical Bulletin. 2007; 30(11): 2079-2083.
150. Li X, He DL, Zhang LL, Chen XF, Luo Y, Sheng BW and Yu LH. [the protective effects of three components isolated from astragalus membranaceus on shock wave lithotripsy induced kidney injury in rabbit model]. Zhonghua Yi Xue Za Zhi. 2005; 85(31): 2201-2206.
151. Zhang WD, Chen H, Zhang C, Liu RH, Li HL and Chen HZ. Astragaloside iv from astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Medica. 2006; 72(1): 4-8.
152. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry. 1976; 72: 248-254.
153. Leaback D and Walker P. Studies on glucosaminidase. 4. The fluorimetric assay of n-acetyl-beta-glucosaminidase. Biochemical Journal. 1961; 78: 151-156.
154. Linko-Lopponen S. Fluorometric measurement of urinary n-acetyl-beta-d-glucosaminidase and its correlation to uremia. Clinica Chimica Acta. 1986; 160(2): 123-127.
155. Ai P, Yong G, Dingkun G, Qiuyu Z, Kaiyuan Z and Shanyan L. Aqueous extract of astragali radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide. Journal of Ethnopharmacology. 2008; 116(3): 413-421.
156. Li W and Fitzloff JF. Determination of astragaloside iv in radix astragali (astragalus membranaceus var. Monghulicus) using high-performance liquid chromatography with evaporative light-scattering detection. Journal of Chromatographic Science. 2001; 39(11): 459-462.
157. 楊文淇, "馬兜鈴酸腎症在純系小鼠的確立與柴胡在此腎炎模型的藥效評估," 藥學系碩士班 , 台北醫學大學, 台北市, 2005.
158. Song J, Meng L, Li S, Qu L and Li X. A combination of chinese herbs, astragalus membranaceus var. Mongholicus and angelica sinensis, improved renal microvascular insufficiency in 5/6 nephrectomized rats. Vascular Pharmacology. 2009; 50(5-6): 185-193.
159. Yin X, Zhang Y, Wu H, Zhu X, Zheng X, Jiang S, Zhuo H, Shen J, Li L and Qiu J. Protective effects of astragalus saponin i on early stage of diabetic nephropathy in rats. Journal of Pharmacological Sciences. 2004; 95(2): 256-266.
160. Qu ZL, Dong H and Wang SD. [effects of astragalus injection on renal function in patients after cardiac valve replacement with cardiopulmonary bypass]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009; 29(4): 313-316.
161. Yang L, Li XM and Wang HY. A comparative study of manchurian dutchmanspipe and antibiotics induced acute tubular necrosis in renal cellular biological features. Chinese Journal of Integrated Traditional & Western Medicine. 2003; 23(5): 329-334.
162. Li B, Li XM, Zhang CY, Wang X and Cai SQ. Cellular mechanism of renal proximal tubular epithelial cell injury induced by aristolochic acid i and aristololactam i. Beijing Da Xue Xue Bao. 2004; 36(1): 36-40.
163. Zuo C, Xie XS, Qiu HY, Deng Y, Zhu D and Fan JM. Astragalus mongholicus ameliorates renal fibrosis by modulating hgf and tgf-beta in rats with unilateral ureteral obstruction. Journal of Zhejiang University-SCIENCE B. 2009; 10(5): 380-390.
164. Zhang YW, Xie D, Xia B, Zhen RT, Liu IM and Cheng JT. Suppression of transforming growth factor-beta1 gene expression by danggui buxue tang, a traditional chinese herbal preparation, in retarding the progress of renal damage in streptozotocin-induced diabetic rats. Hormone and Metabolic Research. 2006; 38(2): 82-88.
165. Yang Y, Yang S, Chen M, Zhang X and Zou Y. Compound astragalus and salvia miltiorrhiza extract exerts anti-fibrosis by mediating tgf-beta/smad signaling in myofibroblasts. Journal of Ethnopharmacology. 2008; 118(2): 264-270.
166. Okada H, Watanabe Y, Inoue T, Kobayashi T, Kanno Y, Shiota G, Nakamura T, Sugaya T, Fukamizu A and Suzuki H. Transgene-derived hepatocyte growth factor attenuates reactive renal fibrosis in aristolochic acid nephrotoxicity. Nephrol Dial Transplant. 2003; 18(12): 2515-2523.
167. Klahr S and Morrissey JJ. The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease. Kidney International. Supplement. 2000; 75: S7-14.
168. Chen W, Li YM and Yu MH. Astragalus polysaccharides: An effective treatment for diabetes prevention in nod mice. Experimental and Clinical Endocrinology and Diabetes. 2008; 116(8): 468-474.
169. Zhang RP, Zhang XP, Ruan YF, Ye SY, Zhao HC, Cheng QH and Wu DJ. Protective effect of radix astragali injection on immune organs of rats with obstructive jaundice and its mechanism. World Journal of Gastroenterology. 2009; 15(23): 2862-2869.
170. Zhang WJ, Hufnagl P, Binder BR and Wojta J. Antiinflammatory activity of astragaloside iv is mediated by inhibition of nf-kappab activation and adhesion molecule expression. Journal of Thrombosis and Haemostasis. 2003; 90(5): 904-914. |