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系統識別號 U0007-1901201714162700
論文名稱(中文) 大豆蛋白對非酒精性脂肪肝病患者之影響
論文名稱(英文) The effects of soy protein on patients with non-alcoholic fatty liver disease
校院名稱 臺北醫學大學
系所名稱(中) 保健營養學研究所
系所名稱(英) Graduate Institute of Nutrition and Health
學年度 105
學期 1
出版年 106
研究生(中文) 火柔中
研究生(英文) Rou-Jong Huoo
學號 G556103001
學位類別 碩士
語文別 中文
口試日期 2017-01-03
論文頁數 101頁
口試委員 委員-王靜瓊
委員-羅慧珍
指導教授-陳俊榮
中文關鍵字 大豆蛋白  非酒精性脂肪肝病  谷氨酸丙酮酸轉氨酶  腸道菌相 
英文關鍵字 Soy protein  Non-alcoholic fatty liver disease (NAFLD)  Alanine aminotransferase (ALT)  gut microflora 
學科別分類
中文摘要 非酒精性脂肪肝在台灣盛行率約11.4% ~ 41%,是一重大的健康課題。本研究設計以單臂、開放性、為期十二週的臨床試驗,使用大豆蛋白介入非酒精性脂肪肝患者,比較介入後血中ALT改善狀況之臨床試驗。受試者被給予含大豆蛋白之補充劑,每日早餐食用一份,連續十二週,同時不改變飲食及生活習慣。評估項目包括:血液生化值、肝脂肪纖維化掃描以及腸道菌相。最終有28名受試者完成研究,研究結果發現大豆蛋白補充劑介入12週後ALT顯著下降,HDL-C及IGFBP-3顯著上升。大豆蛋白的補充能顯著降低其中25名非酒精性脂肪肝病患者的ALT,同時本研究也發現大豆蛋白可能改善與代謝症候群相關的臨床指標。
英文摘要 In Taiwan, the issue of NAFLD is important which’s prevalence is about 11.4% ~ 41%. This study is a single arm, open labeled, 12 weeks clinical trial to evaluate the effect of soy protein supplementation on ALT function. Supplements were consumed as a beverage once daily in breakfast. Participants were provided the treatment for 12 weeks and keep the original dietary behavior and lifestyle. The examination includes blood biochemical parameters, fibroscan and gut microflora. A total of 28 patients enrolled in this study. Each patient completed blood examination, physical examination, FibroScan test, and diet questionnaire before and after soy protein treatment. The comparisons of examination values between patients before and after soy protein treatment showed that there were significant difference on ALT, HDL- cholesterol and IGFBP-3. Soy protein supplementations significantly reduced the ALT level in 25 NAFLD patients. This study also showed that soy protein could improve the clinical characteristics related with metabolic syndrome.
論文目次 目錄
摘要 V
Abstract VI
第一章 研究動機與目的 1
第二章 文獻回顧 3
第一節 NAFLD致病機轉 3
第二節 大豆蛋白 3
第三節 大豆蛋白對肝發炎指標之影響 4
第四節 類胰島素生長因子結合蛋白3 6
第三章 材料與方法 7
第一節 試驗設計 7
第二節 受試者 7
第三節 大豆蛋白補充劑介入方式 9
第四節 受試者遵從度 11
第五節 樣本收集 12
第六節 分析項目 13
第七節 統計方法 25
第四章 結果 26
第五章 討論 28
第六章 參考文獻 33
附錄目錄
附錄 一 40
附錄 二 72
附錄 三 76
附錄 四 80
附錄 五 94
表格目錄
表一 大豆蛋白介入前後28名患者身體檢查值的比較 97
表二 大豆蛋白介入前後28名患者血液檢查值的比較 98
表三 大豆蛋白介入前後28名患者肝臟脂肪纖維化掃描結果的比較 99
表四 大豆蛋白介入前,15位患者的腸道菌群分析結果 100
圖目錄
圖一 15名受試者在大豆蛋白介入前的腸道菌相箱型圖 101
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